Olaparib
- BNF:
- Not listed
- Status:
- Do Not Prescribe (DNP), Red
- Decision Date:
- February 2016
Comments
RED:
- NICE TA620 replaces NICE TA381 for maintenance treatment of relapsed platinum-sensitive ovarian fallopian tube and peritoneal cancer. (Decision date - February 2020)
- NICE TA598 - maintenance treatment of BRCA mutation-positive advanced ovarian,
fallopian tube or peritoneal cancer. (Decision date - September 2019)
- NICE TA693 - Olaparib plus bevacizumab for
maintenance treatment of advanced ovarian, fallopian tube or primary peritoneal
cancer (Decision date - May 2021)
- for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer. NHSE commissioned (Decision date - May 2023)
- NICE TA886 - Olaparib for adjuvant treatment of BRCA mutation-positive HER2-negative high-risk early breast cancer after chemotherapy. (Decision date - June 2023)
- NICE TA887 - Olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer. (Replaces TA831) (Decision date - June 2023)
- NICE TA908 - Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapy (managed access review of NICE TA620) (Decision date - Aug 2023)
- NICE TA946 - Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer. NHSE commissioned (Decision date - February 2024)
- NICE TA951 - Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancer. NHSE commissioned. (Decision date - March 2024)
- NICE TA962 - For maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy. NHSE commissioned. (Decision date - April 2024)
DNP:
- NICE TA750 - Olaparib for maintenance treatment of BRCA mutation-positive metastatic pancreatic cancer after platinum-based chemotherapy (terminated appraisal) (Decision date - February 2022)
- NICE TA762 - Olaparib for treating BRCA mutation-positive HER2-negative
metastatic breast cancer after chemotherapy (terminated appraisal) (Decision date - March 2022)
Black Drug Classifications
- 6: Have NICE guidance that recommends they should not be used
Red Drug Classifications
- 1: Requiring specialist assessment to enable patient selection, initiation and ongoing treating
- 2: Requiring long term on-going monitoring of efficacy by a specialist and not suitable for shared care
- 3: Requiring long term on-going monitoring of toxicity by a specialist (either because of difficulty in recognising side effects or high cost of investigations to identify toxicity)
- 8. NHS England commissioned – to be used in line with NHSE commissioning intentions
search again